Wells PS, Anderson DR, Rodger M, Ginsberg JS, Kearon C, Gent M, et al.

"Derivation of a simple clinical model to categorize patients probability of pulmonary embolism:
increasing the models utility with the SimpliRED D-dimer."

Thromb Haemost. 2000 Mar;83(3):416-20

I➜In 1995, Wells et al. initially developed a prediction rule (based on a literature search) Diagnosis of pulmonary embolism Pulmonary Embolism (PE), based on clinical criteria. The prediction rule was revised first in 1998 and further revised when simplified during a validation by Wells et al. in 2000. In the 2000 publication, Wells proposed two different scoring systems using cut-offs of 2 or 4 with the same prediction rule. In 2001, Wells published results using the more conservative cut-off of 2 to create three categories. An additional version, the "modified extended version", using the more recent cut-off of 2 but including findings from Wells's initial studies were proposed.

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